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Chlorphenesin

Catalog No. DB00856 Name DrugBank
CAS Number 104-29-0 Website http://www.ualberta.ca/
M. F. C9H11ClO3 Telephone (780) 492-3111
M. W. 202.63484 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 734

SYNONYMS

IUPAC name
3-(4-chlorophenoxy)propane-1,2-diol
IUPAC Traditional name
C9H11ClO3
Brand Name
Gechophen
Mycil
Adermykon
Demykon
Gecophen
Maolate
Synonyms
Chlorophenesin
p-Chlorophenyl
Clorfenesina [INN-Spanish]
Chlorphenesine [INN-French]
alpha-Glyceryl ether
Chlorphenesinum [INN-Latin]
p-Chlorophenyl glyceryl ether

DATABASE IDS

PubChem SID 46504714
CAS Number 104-29-0
PubChem CID 7697

PROPERTIES

Hydrophobicity(logP) 1.2
Solubility 1E+004 mg/L

DETAILS

Description (English)
Item Information
Drug Groups approved
Description A centrally acting muscle relaxant. Its mode of action is unknown. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1203)
Indication Used, along with rest and physical therapy, to treat injuries and other painful muscular conditions. Investigated for use in trigeminal neuralgia (tic douloureux), a neuropathic disorder characterized by severe facial pain. Was investigated as a modulator of histamine release.
Pharmacology Chlorphenesin is a muscle relaxant. It blocks nerve impulses (or pain sensations) that are sent to the brain.
Toxicity Symptoms of a chlorphenesin overdose include drowsiness and nausea.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic. 85% of a dose excreted within 24 hours as the glucuronide metabolite.
Absorption Rapid and complete.
Half Life 2.3-5 hours
References
Malley A, Baecher L: Inhibition of histamine and SRS-A from monkey lung tissue by chlorophenesin. J Immunol. 1971 Aug;107(2):586-8. [Pubmed]
Kurachi M, Aihara H: Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats. Jpn J Pharmacol. 1984 Sep;36(1):7-13. [Pubmed]
Dalessio DJ: Medical treatment of the major neuralgias. Semin Neurol. 1988 Dec;8(4):286-90. [Pubmed]
External Links
Drugs.com

REFERENCES

  • Malley A, Baecher L: Inhibition of histamine and SRS-A from monkey lung tissue by chlorophenesin. J Immunol. 1971 Aug;107(2):586-8. Pubmed
  • Kurachi M, Aihara H: Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats. Jpn J Pharmacol. 1984 Sep;36(1):7-13. Pubmed
  • Dalessio DJ: Medical treatment of the major neuralgias. Semin Neurol. 1988 Dec;8(4):286-90. Pubmed