Ranitidine Hydrochloride

• Catalog No.: S1801
• CAS Number: 66357-59-3
• M. F.: C13H23ClN4O3S
• M. W.: 350.86472
• Storage: -20°C

SYNONYMS

• IUPAC name: [(E)-1-({2-[({5-[(dimethylamino)methyl]furan-2-yl}methyl)sulfanyl]ethyl}amino)-2-nitroethenyl](methyl)amine hydrochloride
• IUPAC Traditional name: [(E)-1-({2-[({5-[(dimethylamino)methyl]furan-2-yl}methyl)sulfanyl]ethyl}amino)-2-nitroethenyl](methyl)amine hydrochloride
• Synonyms: Zantac; Azantac; AH 19065

DATABASE IDS

• CAS Number: 66357-59-3

PROPERTIES

• Salt Data: Hydrochloride
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Metabolic Disease
Biological Activity:
Ranitidine (Zantac) is a histamine H2-receptor antagonist with IC50 of 3.3 ± 1.4 µM. It inhibits stomach acid production. It is also used alongside fexofenadine and other antihistamines for the treatment of skin conditions such as hives. It has 10% the affinity that cimetidine has to CYP450 so it causes fewer side effects, but other H2 blockers famotidine and nizatidine have no CYP450 significant interactions. [1][2]

REFERENCES

• Herling AW et al. Agents Actions. 1987 Feb;20(1-2)