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Teniposide

Catalog No. S1787 Name Selleck Chemicals
CAS Number 29767-20-2 Website http://www.selleckchem.com
M. F. C32H32O13S Telephone (877) 796-6397
M. W. 656.65368 Fax (832) 582-8590
Purity Email sales@selleckchem.com
Storage -20°C Chembase ID: 72802

SYNONYMS

IUPAC name
(10R,11R,15R,16S)-16-{[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-(thiophen-2-yl)-hexahydro-2H-pyrano[3,2-d][1,3]dioxin-6-yl]oxy}-10-(4-hydroxy-3,5-dimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0^{3,7}.0^{11,15}]hexadeca-1,3(7),8-trien-12-one
IUPAC Traditional name
vehem
Synonyms
NSC 122819
Vumon
VM-26
Vehem

DATABASE IDS

CAS Number 29767-20-2

PROPERTIES

Salt Data Free Base
Storage Condition -20°C

DETAILS

Description (English)
Research Area: Cancer
Biological Activity:
Teniposide(Vumon) is a chemotherapeutic medication mainly used in the treatment of childhood acute lymphocytic leukemia (ALL). It is in a class of drugs known as podophyllotoxin derivatives and slows the growth of cancer cells in the body. Teniposide causes dose-dependent single- and double-stranded breaks in DNA and DNA-protein cross-links. The mechanism of action appears to be related to the inhibition of type II topoisomerase activity since teniposide does not intercalate into DNA or bind strongly to DNA. [1]

REFERENCES

  • http://en.wikipedia.org/wiki/Teniposide