Glyburide

• Catalog No.: S1716
• CAS Number: 10238-21-8
• M. F.: C23H28ClN3O5S
• M. W.: 494.00352
• Storage: -20°C

SYNONYMS

• IUPAC name: 5-chloro-N-[2-(4-{[(cyclohexylcarbamoyl)amino]sulfonyl}phenyl)ethyl]-2-methoxybenzamide
• IUPAC Traditional name: glibenclamide
• Synonyms: Glycron; Glynase; Glibenclamide; Micronase

DATABASE IDS

• CAS Number: 10238-21-8

PROPERTIES

• Salt Data: Free Base
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Endocrinology
Biological Activity:
Glyburide (Diabeta)  is an anti-diabetic drug in a class of medications known as sulfonylureas, closely related to sulfa drugs. The drug works by inhibiting ATP-sensitive potassium channels in pancreatic beta cells. This inhibition causes cell membrane depolarization, which causes voltage-dependent calcium channels to open, which causes an increase in intracellular calcium in the beta cell, which stimulates insulin release. [1, 2]

REFERENCES

• http://en.wikipedia.org/wiki/Glibenclamide