2,2,2-Trichloroethyl chloroformate

• Catalog No.: L06875
• CAS Number: 17341-93-4
• M. F.: C3H2Cl4O2
• M. W.: 211.85878
• Purity: 97%

SYNONYMS

• Title: 2,2,2-三氯乙基氯甲酯
• IUPAC name: chloro(2,2,2-trichloroethoxy)methanone
• IUPAC Traditional name: chloro(2,2,2-trichloroethoxy)methanone
• Synonyms: 2,2,2-Trichloroethoxycarbonyl chloride; Chloroformic acid 2,2,2-trichloroethyl ester

DATABASE IDS

• MDL Number: MFCD00000810
• CAS Number: 17341-93-4
• Beilstein Number: 970619
• EC Number: 241-363-7

PROPERTIES

• Purity: 97%
• Boiling Point: 171-172°C
• Density: 1.539
• Flash Point: >100°C(212°F)
• Melting Point: 0-2°C
• Refractive Index: 1.4700
• GHS Hazard statements: H301-H330-H314-H318
• European Hazard Symbols: Toxic (T)
• GHS Precautionary statements: P260-P301+P310-P303+P361+P353-P304+P340-P305+P351+P338-P320-P330-P405-P501A
• Risk Statements: 22-23-34
• Safety Statements: 9-20-26-36/37/39-45
• Storage Warning: Moisture Sensitive
• TSCA Listed: 是
• Hazard Class: 6.1
• UN Number: UN3277
• Packing Group: II

REFERENCES

• Reagent for the protection of OH groups as their trichloroethyl (Troc) carbonates, specifically cleaved by reduction with zinc: Tetrahedron Lett., 2555 (1967). For a systematic study of the protection of amines as their Troc-carbamates, see: Synthesis, 268 (1981).
• Preferred to ethyl chloroformate for the N-demethylation of tert-amines, since the resulting carbamate can be cleaved by reductive elimination: Tetrahedron Lett., 1325 (1974); Synth. Commun., 7, 79 (1977).
• Effective reagent for dehydration of primary amides to nitriles: Synth. Commun., 30, 3047 (2000).
• For a brief survey of uses of this reagent in synthesis, see: Synlett, 1473 (2007).