Lamivudine

• Catalog No.: S1706
• CAS Number: 134678-17-4
• M. F.: C8H11N3O3S
• M. W.: 229.25624
• Storage: -20°C

SYNONYMS

• IUPAC name: 4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one
• IUPAC Traditional name: lamivudine
• Synonyms: 3TC; Zeffix; Epivir-HBV; Epivir; Heptovir

DATABASE IDS

• CAS Number: 134678-17-4

PROPERTIES

• Salt Data: Free Base
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Infection
Biological Activity:
Lamivudine(Epivir) is a potent nucleoside analog reverse transcriptase inhibitor with an IC50 of 2.7 mM. [1] The pH-driven uptake of TEA by BBMV (pHin = 6.0, pHout = 7.5) was inhibited by lamivudine. The IC50 value (concentration resulting in 50% inhibition) for the concentration-dependent effect of lamivudine on TEA uptake by BBMV after 30 s was 2668 µM whereas IC50 values for cimetidine and trimethoprim were < 2.5 µM and < 25 µM, respectively. The early uptake of TEA by BLMV was also reduced significantly by lamivudine. The IC50 value for the concentration-dependent effect of lamivudine on uptake of TEA by BLMV at 30 s was > 25 mM, whereas the IC50 values for cimetidine and trimethoprim were 2116 µM and 445µM, respectively. [2]

REFERENCES

• Takubo T et al. J Pharm Pharmacol. 2000 May;52(5)