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Meprednisone

Catalog No. S1689 Name Selleck Chemicals
CAS Number 1247-42-3 Website http://www.selleckchem.com
M. F. C22H28O5 Telephone (877) 796-6397
M. W. 372.45472 Fax (832) 582-8590
Purity Email sales@selleckchem.com
Storage -20°C Chembase ID: 72784

SYNONYMS

IUPAC name
(1S,2R,10S,11S,13S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione
IUPAC Traditional name
methylprednisone
Synonyms
Betapar
Betanisona

DATABASE IDS

CAS Number 1247-42-3

PROPERTIES

Salt Data Free Base
Storage Condition -20°C

DETAILS

Description (English)
Research Area: Inflammation, Endocrinology
Biological Activity:
Betapar(Meprednisone) is a glucocorticoid and a methylated derivative of prednisone. [1]The methylprednisone to MPL area under the curve ratio decreased from 0.19 +/- 0.04 in control to 0.14 +/- 0.03 in ketoconazole-treated rats (P less than .05) due to altered interconversion between these steroids. An improved pharmacokinetic/dynamic receptor/gene-mediated model characterized the steroid receptor binding and induction of tyrosine aminotransferase activity after i.v. MPL sodium succinate (10 mg/kg). In contrast to previous in vitro studies, ketoconazole at maximally tolerated doses failed to antagonize the steroid receptor-mediated activity of MPL. [2]

REFERENCES

  • http://en.wikipedia.org/wiki/Meprednisone