Isradipine

• Catalog No.: S1662
• CAS Number: 75695-93-1
• M. F.: C19H21N3O5
• M. W.: 371.38714
• Storage: -20°C

SYNONYMS

• IUPAC name: 3-methyl 5-propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• IUPAC Traditional name: isradipine
• Synonyms: Prescal; Clivoten; Esr; PN-200-110; DynaCirc

DATABASE IDS

• CAS Number: 75695-93-1

PROPERTIES

• Salt Data: Free Base
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Cardiovascular Disease
Biological Activity:
Isradipine(Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM.It is usually prescribed for the treatment of high blood pressure in order to reduce the risk of stroke and heart attack. [1] the interactive effects of isradipine and blockers or enhancers of nonselective cation channels (NSCCs) and Na+/Ca2+ exchangers (NCXs). Normal human gingival fibroblast Gin-1 cells were used. The [Ca2+]i was measured with the Ca2+-sensitive fluorescent dye fura-2/AM. Changes in the fluorescence intensity of fura-2 in the cells were recorded with a video-imaging analysis system. Ca2+ antagonists (nifedipine, verapamil, and diltiazem in the concentration range of 1 to 20 μM) other than isradipine also raised the [Ca2+]i. [2] 

REFERENCES

• Hattori T et al. Eur J Med Res. 2006 Mar 27;11(3)