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Nitrofurazone

Catalog No. S1644 Name Selleck Chemicals
CAS Number 59-87-0 Website http://www.selleckchem.com
M. F. C6H6N4O4 Telephone (877) 796-6397
M. W. 198.13624 Fax (832) 582-8590
Purity Email sales@selleckchem.com
Storage -20°C Chembase ID: 220

SYNONYMS

IUPAC name
[(E)-[(5-nitrofuran-2-yl)methylidene]amino]urea
IUPAC Traditional name
nitrofurazone
Synonyms
Nitrofural
ACTIN-N
Furacilin
Otofuran

DATABASE IDS

CAS Number 59-87-0

PROPERTIES

Salt Data Free Base
Storage Condition -20°C

DETAILS

Description (English)
Research Area: Infection
Biological Activity:
Nitrofurazone is a topical anti-infective agent with an IC50 of 22.83 ± 1.2 µM, and effective against gram-negative and gram-positive bacteria. (Rat LD50 = 590 mg/kg)[1] Nitrofurazone (NF) and its derivative, hydroxymethylnitrofurazone (NFOH), have presented antichagasic activity. In vitro cruzain inhibition tests were performed for both compounds, and the 50% inhibitory concentration (IC50) for NF and NFOH presented values of 22.83 ± 1.2 µM and 10.55 ± 0.81 µM, respectively. AM1 semi-empirical molecular modeling studies were performed to understand the activity of the compounds, corroborating the observed cruzain inhibitory activity. [2]

REFERENCES

  • http://en.wikipedia.org/wiki/Nitrofurazone