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Methyldopa

Catalog No. S1642 Name Selleck Chemicals
CAS Number 555-30-6 Website http://www.selleckchem.com
M. F. C10H13NO4 Telephone (877) 796-6397
M. W. 211.21452 Fax (832) 582-8590
Purity Email sales@selleckchem.com
Storage -20°C Chembase ID: 843

SYNONYMS

IUPAC name
(2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid
IUPAC Traditional name
methyldopa
Synonyms
Aldoril
Dopegyt
Dopamet

DATABASE IDS

CAS Number 555-30-6

PROPERTIES

Salt Data Free Base
Storage Condition -20°C

DETAILS

Description (English)
Research Area: Neurological Disease
Biological Activity:
Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg. It is also known as aromatic L-amino acid decarboxylase, which converts L-DOPA into dopamine. Dopamine is a precursor for norepinephrine (noradrenaline) and subsequently epinephrine (adrenaline). This inhibition results in reduced dopaminergic and adrenergic neurotransmission in the peripheral nervous system. [1] The antihypertensive agents lofexidine (ED50, 0.03 mg/kg), guanabenz (ED50, 0.019 mg/kg), p-aminoclonidine (ED50, 0.23 mg/kg), methyldopa (ED50, 21.8 mg/kg), hydralazine (ED50, 0.98 mg/kg), prazosin (ED50, 0.72 mg/kg), minoxidil (ED50, 12.4 mg/kg) and pergolide (ED50, 0.021 mg/kg) were generalized to clonidine in a dose-dependent manner. [2] Methyldopa (Aldomet) is a psychoactive molecule used as a sympatholytic or antihypertensive.o

REFERENCES

  • http://en.wikipedia.org/wiki/Methyldopa