Chlorothiazide

• Catalog No.: S1641
• CAS Number: 58-94-6
• M. F.: C7H6ClN3O4S2
• M. W.: 295.72324
• Storage: -20°C

SYNONYMS

• IUPAC name: 6-chloro-1,1-dioxo-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide
• IUPAC Traditional name: flumen
• Synonyms: Diuril; Chlotride

DATABASE IDS

• CAS Number: 58-94-6

PROPERTIES

• Salt Data: Free Base
• Solubility: DMSO
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Cardiovascular disease
Biological Activity:
Chlorothiazide is a diuretic and antihypertensive. By increasing the amount of salt and water that the kidneys remove from the blood, the diuretic can lower blood pressure and help with water retention. [1] The corresponding IC50 values for the thiazide diuretics chlorothiazide, cyclothiazide, hydrochlorothiazide,and trichlormethiazide were 3.8, 84.3, 67.3 and 19.2 mM) respectively. [2]

REFERENCES

• Rizwan AN et al. Pharm Res. 2007 Mar;24(3):450-70.