(Trimethylsilyl)acetic acid

• Catalog No.: L03903
• CAS Number: 2345-38-2
• M. F.: C5H12O2Si
• M. W.: 132.23308
• Purity: 98+%

SYNONYMS

• Title: (三甲基甲硅烷基)乙酸
• IUPAC name: 2-(trimethylsilyl)acetic acid
• IUPAC Traditional name: acetic acid, (trimethylsilyl)-

DATABASE IDS

• EC Number: 219-067-4
• CAS Number: 2345-38-2
• MDL Number: MFCD00042651
• Beilstein Number: 1679394

PROPERTIES

• Purity: 98+%
• Boiling Point: 90-95°C/10mm
• Flash Point: 95°C(203°F)
• Melting Point: 40-42°C
• GHS Hazard statements: H315-H319-H335-H303
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P261-P305+P351+P338-P302+P352-P321-P405-P501A
• Risk Statements: 36/37/38
• RTECS: AK0843500
• Safety Statements: 26-37
• Storage Warning: Moisture Sensitive
• TSCA Listed: 是

REFERENCES

• The dilithiated derivative can undergo the Peterson olefination reaction (see Appendix 4), to give substituted acrylic acids, with alkyl halides to give alkyl silylacetic acids and with oxiranes to give -lactones: J. Chem. Soc., Chem. Commun., 537 (1975):
  
• Dehydration with DCC and Et₃N gives the ketene which is remarkably stable, showing little tendency to dimerize: Synthesis, 568 (1989).