Allopurinol

• Catalog No.: S1630
• CAS Number: 315-30-0
• M. F.: C5H4N4O
• M. W.: 136.11146
• Storage: -20°C

SYNONYMS

• IUPAC name: 1H,2H,4H-pyrazolo[3,4-d]pyrimidin-4-one
• IUPAC Traditional name: ALLO
• Synonyms: Lopurin; Aloprim; Zyloprim

DATABASE IDS

• CAS Number: 315-30-0

PROPERTIES

• Salt Data: Free Base
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Neurological Disease
Biological Activity:
Allopurinol (Zyloprim) is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 µM.Xanthine oxidase is responsible for the successive oxidation of hypoxanthine and xanthine resulting in the production of uric acid, the product of human purine metabolism. [1] The inhibition of XO activity by 6-aminopurine (IC50=10.89±0.13 µM) and its analogues was compared with that by allopurinol (IC50=7.82±0.12 µM). Among these analogues, 2-chloro-6(methylamino)purine (IC50=10.19±0.10 µM) and 4-aminopyrazolo[3,4-d] pyrimidine (IC50=30.26±0.23 µM) were found to be potent inhibitors of XO. [2]

REFERENCES

• http://en.wikipedia.org/wiki/Allopurinol