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Nitazoxanide

Catalog No. S1627 Name Selleck Chemicals
CAS Number 55981-09-4 Website http://www.selleckchem.com
M. F. C12H9N3O5S Telephone (877) 796-6397
M. W. 307.28196 Fax (832) 582-8590
Purity Email sales@selleckchem.com
Storage -20°C Chembase ID: 389

SYNONYMS

IUPAC name
2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate
IUPAC Traditional name
nitazoxanide

DATABASE IDS

CAS Number 55981-09-4

PROPERTIES

Salt Data Free Base
Storage Condition -20°C

DETAILS

Description (English)
Research Area: Infection
Biological Activity:
Nitazoxanide(Alinia, Annita) is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM) The anti- protozoal activity of nitazoxanide is believed to be due to interference with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme dependent electron transfer reaction which is essential to anaerobic energy metabolism. [1] It has also been shown to have activity against influenza A virus. Nitazoxanide and tizoxanide inhibited virus replication of all canine influenza virus with 50% and 90% inhibitory concentrations ranging from 0.17 to 0.21 μM and from 0.60 to 0.76 μM, respectively. [2]

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