Alendronate sodium

• Catalog No.: S1624
• CAS Number: 121268-17-5
• M. F.: C4H18NNaO10P2
• M. W.: 325.123712
• Storage: -20°C

SYNONYMS

• IUPAC name: sodium trihydrate hydrogen (4-amino-1-hydroxy-1-phosphonobutyl)phosphonate
• IUPAC Traditional name: sodium trihydrate alendronate(1-)
• Synonyms: Fosamax

DATABASE IDS

• CAS Number: 121268-17-5

PROPERTIES

• Salt Data: Sodium
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Metabolic Disease, Endocrinology
Biological Activity:
Alendronate (Fosamax) is a farnesyl diphosphate synthase inhibitor with IC50 of 460 nM. It is a nitrogen-containing bisphosphate that acts as a robust inhibitor of bone resorption and induces apoptosis in osteoclasts. [1] It causes disruption of the ruffled border and actin cytoskeleton of osteoclasts and induces in vitro apoptosis of osteoclasts and macrophages by inhibiting farnesyl diphosphate synthase (IC50 = 460 nM). [2] It efficiently chelates metal ions and functions as a broad-spectrum MMP inhibitor (IC50 ~ 40 - 70 µM). And it also displays antimetastatic, anti-invasive and cell-adhesion-promoting properties (IC50 ~ 1 pM, in vitro invasion of prostate cancer cells).

REFERENCES

• Jackson NM et al. Drug Metab Dispos. 2008 Oct; 36