Methoxyacetyl chloride

• Catalog No.: L03210
• CAS Number: 38870-89-2
• M. F.: C3H5ClO2
• M. W.: 108.5236
• Purity: 97%, stab. with ca 0.3% magnesium oxide

SYNONYMS

• Title: 甲氧基乙酰氯
• IUPAC name: 2-methoxyacetyl chloride
• IUPAC Traditional name: methoxy-acetyl chloride

DATABASE IDS

• MDL Number: MFCD00000728
• CAS Number: 38870-89-2
• EC Number: 254-169-2
• Beilstein Number: 1740244

PROPERTIES

• Purity: 97%, stab. with ca 0.3% magnesium oxide
• Boiling Point: 112-113°C
• Density: 1.185
• Flash Point: 28°C(82°F)
• Melting Point: <-40°C
• Refractive Index: 1.4240
• GHS Hazard statements: H331-H314-H318-H226
• European Hazard Symbols: X
• European Hazard Symbols: Corrosive (C)
• GHS Precautionary statements: P280-P305+P351+P338-P309-P310
• Risk Statements: 10-20-34
• Safety Statements: 26-36/37/39-45
• Storage Warning: Moisture Sensitive
• TSCA Listed: 否
• Hazard Class: 8
• UN Number: UN2920
• Packing Group: II

REFERENCES

• Reagent for the chloromethylation of aromatics under Friedel-Crafts conditions, avoiding the use of chloromethyl methyl ether: Tetrahedron Lett., 24, 1933 (1983). For a study of the kinetics of chloromethylation of benzene and toluene in the presence of SnCl₄, see: J. Org. Chem., 62, 2694 (1997). Compare Methoxyacetic acid, B22917.
• Has also been used for the protection of alcohols as methoxyacetate esters, formed in the presence of pyridine, and cleaved using methanolic or aqueous ammonia ca. 20x faster than acetate: Tetrahedron Lett., 4273 (1968). Selective cleavage with Yb(OTf)₃: J. Org. Chem., 61, 4491 (1996), or ethanolamine in IPA: J. Org. Chem., 60, 331 (1995), have also been reported.