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Methimazole

Catalog No. S1609 Name Selleck Chemicals
CAS Number 60-56-0 Website http://www.selleckchem.com
M. F. C4H6N2S Telephone (877) 796-6397
M. W. 114.16884 Fax (832) 582-8590
Purity Email sales@selleckchem.com
Storage -20°C Chembase ID: 643

SYNONYMS

IUPAC name
1-methyl-2,3-dihydro-1H-imidazole-2-thione
IUPAC Traditional name
methimazole
Synonyms
Thiamazole
Metazolo
Basolan

DATABASE IDS

CAS Number 60-56-0

PROPERTIES

Salt Data Free Base
Storage Condition -20°C

DETAILS

Description (English)
Research Area: Endocrinology
Biological Activity:
Methimazole(Tapazole, Northyx) is an antithyroid medicine. Methimazole is used to treat hyperthyroidism, a condition where the thyroid gland produces too much thyroid hormone. It is also used before thyroid surgery or radioactive iodine treatment. [1] Methimazole inhibits the addition of iodine to thyroglobulin by the enzyme thyroperoxidase, a necessary step in the synthesis of triiodothyronine(T3) and thyroxine(T4). It does not inhibit the action of the sodium-dependent iodide transporter located on follicular cells’ basolateral membranes. Inhibition of this step requires competitive inhibitors such as perchlorate and thiocyanate. [1]

REFERENCES

  • http://en.wikipedia.org/wiki/Methimazole