SKF 89976A hydrochloride

• Catalog No.: S1589
• CAS Number: 85375-15-1
• M. F.: C22H26ClNO2
• M. W.: 371.90034
• Storage: -20°C

SYNONYMS

• IUPAC name: 1-(4,4-diphenylbut-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride
• IUPAC Traditional name: 1-(4,4-diphenylbut-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride

DATABASE IDS

• CAS Number: 85375-15-1

PROPERTIES

• Target: Angiotensin receptor
• Salt Data: hydrochloride
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Neurological Disease
Biological Activity:
SKF 89976A is a GABA transporter type 1 inhibitor with IC50 of 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively. It is selective for GAT-1. It inhibits transport current competitively (Ki = 7 μM) and transmitter-gated current non-competitively (Ki = 0.03 nM). Able to pass the blood-brain barrier after systemic administration and is active in vivo. [1]References on SKF 89976A HCl[1] Acta Physiol Scand. , 152(2):173-9, 1994 Oct.

REFERENCES

• Lewin L et al. Acta Physiol Scand. 1994 Oct;152(2)