Trifluoroacetaldehyde ethyl hemiacetal

• Catalog No.: L01554
• CAS Number: 433-27-2
• M. F.: C4H7F3O2
• M. W.: 144.0923896
• Purity: tech. 80%

SYNONYMS

• Title: 三氟乙醛乙基半缩醛, tech.
• IUPAC name: 1-ethoxy-2,2,2-trifluoroethan-1-ol
• IUPAC Traditional name: 1-ethoxy-2,2,2-trifluoroethanol

DATABASE IDS

• Beilstein Number: 906797
• CAS Number: 433-27-2
• MDL Number: MFCD00000441
• EC Number: 207-087-6

PROPERTIES

• Purity: tech. 80%
• Boiling Point: 104-106°C
• Density: 1.230
• Flash Point: 39°C(102°F)
• Refractive Index: 1.3430
• GHS Hazard statements: H301-H315-H319-H226
• European Hazard Symbols: X
• GHS Precautionary statements: P210-P301+P310-P303+P361+P353-P305+P351+P338-P405-P501A
• Risk Statements: 10-22-36/38
• RTECS: KK9000000
• Safety Statements: 23-26-36/37
• TSCA Listed: 是
• Hazard Class: 3
• UN Number: UN1989
• Packing Group: III

REFERENCES

• For a review applications in the synthesis of trifluoromethylated compounds, see: Current Org. Chem., 8, 1659 (2004).
• Reacts with nucleophilic organosilanes, e.g. allyltrimethylsilane, TMS cyanide or silyl enol ethers, in the presence of a Lewis acid (ZnI₂ or AlCl₃) to give a series of ɑ-trifluoromethylated alcohols in high yield: Tetrahedron Lett., 33, 1351 (1992).
• The synthesis of ɑ-trifluoromethylated alcohols has also been accomplished by In-mediated reaction with allylic bromides in water: Chem. Commun., 1929 (1996).