2-Acetoxyisobutyryl chloride

• Catalog No.: L00957
• CAS Number: 40635-66-3
• M. F.: C6H9ClO3
• M. W.: 164.58686
• Purity: 98%

SYNONYMS

• Title: 2-乙酰氧基异丁酰氯
• IUPAC name: 1-chloro-2-methyl-1-oxopropan-2-yl acetate
• IUPAC Traditional name: 1-chloro-2-methyl-1-oxopropan-2-yl acetate
• Synonyms: 2-Acetoxy-2-methylpropionyl chloride; 1-Chlorocarbonyl-1-methylethyl acetate

DATABASE IDS

• MDL Number: MFCD00000708
• CAS Number: 40635-66-3
• EC Number: 255-016-2
• Beilstein Number: 507772

PROPERTIES

• Purity: 98%
• Boiling Point: 55-56°C/6mm
• Density: 1.150
• Flash Point: 68°C(154°F)
• Refractive Index: 1.4290
• GHS Hazard statements: H314-H318-H335-H227
• European Hazard Symbols: Corrosive (C)
• GHS Precautionary statements: P210-P260-P303+P361+P353-P305+P351+P338-P405-P501A
• Risk Statements: 14-34-37
• Safety Statements: 26-36/37/39-45
• Storage Warning: Moisture Sensitive
• TSCA Listed: 否
• Hazard Class: 8
• UN Number: UN3265
• Packing Group: II

REFERENCES

• Reagent for conversion of cis-1,2-diols, including nucleosides, via cyclic dioxolanone intermediates, into trans-chloroalkyl acetates. The reaction is selective for the 2'-OH of uridine derivatives and converts pyrimidine nucleosides to their anhydro forms: J. Am. Chem. Soc., 95, 4016 (1973). Application to synthesis of deoxy-sugars, by dechlorination with Bu₃SnH: J. Chem. Soc., Chem. Commun., 677 (1978).
• Reaction of the chloroalkyl acetate (from a cis-glycol) with azide ion provides a route to the cis-amino alcohol: Tetrahedron Lett., 37, 2529 (1996). Compare O-Acetylsalicyloyl chloride, L00919.