Diethyl 2-bromo-2-methylmalonate

• Catalog No.: L00575
• CAS Number: 29263-94-3
• M. F.: C8H13BrO4
• M. W.: 253.09042
• Purity: 98%

SYNONYMS

• Title: 2-溴代-2-甲基丙二酸二乙酯
• IUPAC name: 1,3-diethyl 2-bromo-2-methylpropanedioate
• IUPAC Traditional name: 1,3-diethyl 2-bromo-2-methylpropanedioate
• Synonyms: 2-Bromo-2-methylmalonic acid diethyl ester

DATABASE IDS

• MDL Number: MFCD00009125
• EC Number: 249-541-6
• Beilstein Number: 1779673
• CAS Number: 29263-94-3

PROPERTIES

• Purity: 98%
• Boiling Point: 105-106°C/5mm
• Density: 1.323
• Flash Point: >110°C(230°F)
• Refractive Index: 1.4490
• GHS Hazard statements: H314-H318
• European Hazard Symbols: Corrosive (C)
• GHS Precautionary statements: P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501A
• Risk Statements: 34
• Safety Statements: 26-36/37/39-45
• TSCA Listed: 否
• Hazard Class: 8
• UN Number: UN3265
• Packing Group: II

REFERENCES

• Brominating agent, more reproducible than bromine, for ester enolates: Rec. Trav. Chim., 96, 72 (1977).
• Reacts with nucleophiles at bromine with displacement of the malonate anion. Thus it has been used to introduce the ɑ-methylacetic acid unit at a remote position, asin the -alkylation of unsaturated ketones, in which the displaced malonate anion reacts with the initially-formed ɑ-bromo ketone. This process has been termed "transfer alkylation": J. Am. Chem. Soc., 94, 1790 (1972):