Dimethyl acetylmethylphosphonate

• Catalog No.: L00537
• CAS Number: 4202-14-6
• M. F.: C5H11O4P
• M. W.: 166.112201
• Purity: 97%

SYNONYMS

• Title: 丙酮基膦酸二甲酯
• IUPAC name: dimethyl (2-oxopropyl)phosphonate
• IUPAC Traditional name: dimethyl 2-oxopropylphosphonate
• Synonyms: Acetylmethylphosphonic acid dimethyl ester; Dimethyl acetonylphosphonate

DATABASE IDS

• CAS Number: 4202-14-6
• MDL Number: MFCD00008769
• EC Number: 224-110-5
• Beilstein Number: 1766218

PROPERTIES

• Purity: 97%
• Boiling Point: 121-123°C/11mm
• Density: 1.202
• Flash Point: 93°C(199°F)
• Refractive Index: 1.4390
• GHS Hazard statements: H227
• GHS Precautionary statements: P210-P280-P370+P378A-P403+P235-P501A
• TSCA Listed: 否

REFERENCES

• For use of ?-ketophosphonates in an annulation sequence for building a cyclohexadienone ring onto a cyclic ketone, see: Synthesis, 855 (1982):
  
• Successive treatment with NaH and n-BuLi gives the dianion which can be alkylated or acylated on the terminal position: see. e.g.: Synth. Commun., 22, 219 (1992); J. Chem. Soc., Perkin 1, 2259 (1998).
• Horner-Wadsworth-Emmons precursor of ɑ?-unsaturated ketones.