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Febuxostat

Catalog No. S1547 Name Selleck Chemicals
CAS Number 144060-53-7 Website http://www.selleckchem.com
M. F. C16H16N2O3S Telephone (877) 796-6397
M. W. 316.37484 Fax (832) 582-8590
Purity Email sales@selleckchem.com
Storage -20°C Chembase ID: 72735

SYNONYMS

IUPAC name
2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid
IUPAC Traditional name
febuxostat
Synonyms
Adenuric
TMX-67
Uloric

DATABASE IDS

CAS Number 144060-53-7

PROPERTIES

Target XAO
Salt Data Free Base
Storage Condition -20°C

DETAILS

Description (English)
Research Area: Metabolic Disease
Biological Activity:
Febuxostat (Uloric) is a non-purine selective XAO inhibitor with IC50 of 114 -210 nM.It works by non-competitively blocking the channel leading to the active site on xanthine oxidase. [1] Xanthine oxidase is needed to successively oxidize both hypoxanthine and xanthine to uric acid. Hence, febuxostat inhibits xanthine oxidase, therefore reducing production of uric acid. [2][3]

REFERENCES

  • Gaffo AL et al. Core Evid. 2010 Jun 15;4:25-36