2-Pyrrolidinone hydrotribromide

• Catalog No.: L00177
• CAS Number: 22580-55-8
• M. F.: C12H22Br3N3O3
• M. W.: 496.03338
• Purity: 97%

SYNONYMS

• Title: 2-吡咯烷酮 氢三溴化物
• IUPAC name: dibromane tris(pyrrolidin-2-one) hydrobromide
• IUPAC Traditional name: Brom tris(pyrrolidone) hydrobromide
• Synonyms: Pyrrolidone hydrotribromide; PHT

DATABASE IDS

• MDL Number: MFCD00082241
• CAS Number: 22580-55-8
• EC Number: 245-100-7

PROPERTIES

• Purity: 97%
• Melting Point: 88-90°C
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P261-P305+P351+P338-P302+P352-P321-P405-P501A
• Risk Statements: 36/37/38
• Safety Statements: 26-37
• Storage Warning: Moisture Sensitive
• TSCA Listed: 否

REFERENCES

• See also (2-Carboxyethyl)triphenylphosphonium tribromide, L00553, for alternative reagent.
• Mild, highly selective brominating agent. Ketones can be ɑ-brominated in the presence of a double bond: the low concentration of enol form consumes the bromine as it is slowly liberated: Can. J. Chem., 47, 706 (1969). Acid sensitive substrates can be brominated with PHT with excess pyrrolidinone: Synthesis, 59 (1990). Bromination with PHT is facilitated by the presence of free radicals or trace peroxides (as in THF or dioxane). In DMSO, dehydrobromination may occur: J. Org. Chem., 55, 6161 (1990):