Aztreonam(Azactam)

• Catalog No.: S1505
• CAS Number: 78110-38-0
• M. F.: C13H17N5O8S2
• M. W.: 435.43278
• Storage: -20°C

SYNONYMS

• IUPAC name: 2-{[(Z)-[(2-amino-1,3-thiazol-4-yl)({[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]carbamoyl})methylidene]amino]oxy}-2-methylpropanoic acid
• IUPAC Traditional name: @aztreonam
• Synonyms: SQ 26776; Monobactam; Squibb 26776

DATABASE IDS

• CAS Number: 78110-38-0

PROPERTIES

• Salt Data: Free Base
• Solubility: DMSO
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Infection
Biological Activity:
Aztreonam(Azactam, Cayston) is a synthetic monocyclic beta-lactam antibiotic (a monobactam), with the nucleus based on a simpler monobactam isolated from Chromobacterium violaceum. It inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking. It has a very high affinity for penicillin-binding protein 3 (PBP-3) and mild affinity for PBP-1a. Aztreonam binds to the penicillin-binding proteins of gram-positive and anaerobic bacteria very poorly and is largely ineffective against them. [1]

REFERENCES

• http://en.wikipedia.org/wiki/Aztreonam