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5-Aminolevulinic acid hydrochloride_Molecular_structure_CAS_5451-09-2)
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5-Aminolevulinic acid hydrochloride

Catalog No. S2553 Name Selleck Chemicals
CAS Number 5451-09-2 Website http://www.selleckchem.com
M. F. C5H10ClNO3 Telephone (877) 796-6397
M. W. 167.5908 Fax (832) 582-8590
Purity Email sales@selleckchem.com
Storage -20°C Chembase ID: 68223

SYNONYMS

IUPAC name
5-amino-4-oxopentanoic acid hydrochloride
IUPAC Traditional name
aminolevulinic acid hydrochloride
Synonyms
ALA
Levulan

DATABASE IDS

CAS Number 5451-09-2

PROPERTIES

Salt Data hydrochloride
Storage Condition -20°C

DETAILS

Description (English)
Research Area: Cancer
Biological Activity:
5-Aminolevulinic acid is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles, such as chlorophyll and heme. In mammals, yeast, fungi and the purple bacteria, 5-aminolevulinic acid is formed by the Shemin pathway. Then it is used in the synthesis of hemes, vitamin B12 and bacteriochlorophyll. Two molecules of 5-aminolevulinic acid are condensed to form porphobilinogen. It is the first step compound in the porphyrin synthesis. Aminolevulinic acid HCl (5-aminolevulinic acid HCl) is a prodrug that is metabolized intracellularly to form the photosensitizing molecule protoporphyrin (PpIX). When PpIX is activated by light, cytotoxic reactive oxygen species and free radicals are generated. ALA can diffuse through skin and preferentially localizes in tumors and dysplasic tissue. Subsequent exposure of PpIX-loaded tumor cells to light can destroy the tumor. [1][2]

REFERENCES

  • gura S et al. BMC Res Notes. 2011 Mar 17; 4:66.