Polymyxin B sulphate

• Catalog No.: S1395
• CAS Number: 1405-20-5
• M. F.: C56H100N16O17S
• M. W.: 1301.5552
• Storage: -20°C

SYNONYMS

• IUPAC name: N-[3-amino-1-({1-[(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)carbamoyl]-2-hydroxypropyl}carbamoyl)propyl]-6-methyloctanamide; sulfuric acid
• IUPAC Traditional name: N-[3-amino-1-({1-[(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)carbamoyl]-2-hydroxypropyl}carbamoyl)propyl]-6-methyloctanamide; sulfuric acid
• Synonyms: Poly-RX; Aerosporin; PMB

DATABASE IDS

• CAS Number: 1405-20-5

PROPERTIES

• Salt Data: sulphate
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Infection
Biological Activity:
Polymyxin B is an antibiotic primarily used for resistant gram-negative infections. Polymyxins bind to the cell membrane and alter its structure making it more permeable. The resulting water uptake leads to cell death. They are cationic, basic proteins that act like detergents (surfactants). It is commonly used in the topical first-aid preparation Neosporin. [1]

REFERENCES

• http://www.rxlist.com/polymyxin-b-drug.htm