Pirarubicin

• Catalog No.: S1393
• CAS Number: 72496-41-4
• M. F.: C32H37NO12
• M. W.: 627.63568
• Storage: -20°C

SYNONYMS

• IUPAC name: (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-6-methyl-5-(oxan-2-yloxy)oxan-2-yl]oxy}-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione
• IUPAC Traditional name: (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-6-methyl-5-(oxan-2-yloxy)oxan-2-yl]oxy}-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione
• Synonyms: THP-Adriamycin

DATABASE IDS

• CAS Number: 72496-41-4

PROPERTIES

• Target: topoisomerase
• Salt Data: Free Base
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Cancer
Biological Activity:
Pirarubicin is an anthracycline drug. An analogue of the anthracycline antineoplastic antibiotic doxorubicin. Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines. [1,2]References on Pirarubicin[1] http://www.cancer.gov/drugdictionary/?CdrID=38775, , [2] http://en.wikipedia.org/wiki/Pirarubicin, ,

REFERENCES

• http://en.wikipedia.org/wiki/Pirarubicin