Mizoribine

• Catalog No.: S1384
• CAS Number: 50924-49-7
• M. F.: C9H13N3O6
• M. W.: 259.21602
• Storage: -20°C

SYNONYMS

• IUPAC name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxy-1H-imidazole-4-carboxamide
• IUPAC Traditional name: bredinin
• Synonyms: Bredinin

DATABASE IDS

• CAS Number: 50924-49-7

PROPERTIES

• Target: DNA/RNA synthesis
• Salt Data: Free Base
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Immunology
Biological Activity:
Mizoribine (Bredinin) is an imidazole nucleoside and an immunosuppressive agent with an IC50 of approximately 100 μM. The immunosuppressive effect of mizoribine (Bredinin) has been reported to be due to the inhibition of DNA synthesis in the S phase of the cell cycle. Because of its relative lack of toxicity, during the past decade mizoribine (Bredinin) has been frequently used instead of azathioprine as a component of immunosuppressive drug regimens. Mizoribine (Bredinin) is being used to treat renal transplantation patients, IgA nephropathy, lupus erythematosus, and childhood nephrotic syndrome (NS), and some recent studies have assessed the efficacy of oral mizoribine (Bredinin) pulse therapy for severe lupus nephritis, steroid-resistant NS, and frequently relapsing-steroid-dependent NS. [1][2][3]

REFERENCES

• http://en.wikipedia.org/wiki/Mizoribine