Ramelteon(TAK-375)

• Catalog No.: S1259
• CAS Number: 196597-26-9
• M. F.: C16H21NO2
• M. W.: 259.34344
• Storage: -20°C

SYNONYMS

• IUPAC name: N-{2-[(8S)-1H,2H,6H,7H,8H-indeno[5,4-b]furan-8-yl]ethyl}propanamide
• IUPAC Traditional name: rozerem
• Synonyms: Rozerem; TAK-375

DATABASE IDS

• CAS Number: 196597-26-9

PROPERTIES

• Target: MT
• Salt Data: Free Base
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Cancer
Biological Activity:
Ramelteon is a melatonin receptor agonist with both high affinity for melatonin MT1 (IC50 =28.5 ± 8.55 pM)and MT2 (20.1 ± 9.25 pM)receptors and selectivity over the MT3 receptor. [1]The activity of ramelteon at the MT1 and MT2 receptors is believed to contribute to its sleep-promoting properties. Ramelteon has no appreciable affinity for the GABA receptor complex or for receptors that bind neuropeptides, cytokines, serotonin, dopamine, noradrenaline, acetylcholine, and opiates. [2]

REFERENCES

• http://en.wikipedia.org/wiki/Ramelteon