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Pseudoephedrine

Catalog No. DB00852 Name DrugBank
CAS Number 90-82-4 Website http://www.ualberta.ca/
M. F. C10H15NO Telephone (780) 492-3111
M. W. 165.2322 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 730

SYNONYMS

IUPAC name
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol
IUPAC Traditional name
pseudoephedrine
Brand Name
Psi-Ephedrine
Efidac/24
Sudafed Decongestant 12 Hour
Pseudoephedrine Hcl
Pseudo-12
Maxenal
Balminil Decongestant Syrup
Dimetapp Decongestant Pediatric Drops
Drixoral N.D.
Drixoral Nasal Decongestant
Eltor 120
Genaphed
Myfedrine
Novafed
Pseudo 60's
Trans-Ephedrine
Triaminic AM Decongestant Formula
Triaminic Infant Oral Decongestant Drops
Afrinol
Benylin Decongestant
Besan
Cenafed
D-Pseudoephedrine
Decofed
Dimetapp Decongestant
Efidac 24 Pseudoephedrine Hcl
Pedia Care
Pseudo
Pseudoefedrina [INN-Spanish]
Pseudoephedrine D-Form
Pseudoephedrine Ephedrine
Pseudoephedrinum [INN-Latin]
Psi-Ephedrin
Robidrine
Sudafed
Sudafed 12 Hour
Sudafed Decongestant
Sudafed Decongestant Extra Strength
Afrin
D-Isoephedrine
Isoephedrine
Chlor-Trimeton

DATABASE IDS

PubChem CID 7028
PubChem SID 46508190
CAS Number 90-82-4

PROPERTIES

Hydrophobicity(logP) 1.4
Solubility 7 mg/L

DETAILS

Description (English)
Item Information
Drug Groups approved
Description An alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used in the treatment of several disorders including asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists. [PubChem]
Indication For the treatment of nasal congestion, sinus congestion, Eustachian tube congestion, and vasomotor rhinitis, and as an adjunct to other agents in the optimum treatment of allergic rhinitis, croup, sinusitis, otitis media, and tracheobronchitis. Also used as first-line therapy of priapism.
Pharmacology Pseudoephedrine is a sympathomimetic agent, structurally similar to ephedrine, used to relieve nasal and sinus congestion and reduce air-travel-related otalgia in adults. The salts pseudoephedrine hydrochloride and pseudoephedrine sulfate are found in many over-the-counter preparations either as single-ingredient preparations, or more commonly in combination with antihistamines and/or paracetamol/ibuprofen. Unlike antihistamines, which modify the systemic histamine-mediated allergic response, pseudoephedrine only serves to relieve nasal congestion commonly associated with colds or allergies. The advantage of oral pseudoephedrine over topical nasal preparations, such as oxymetazoline, is that it does not cause rebound congestion (rhinitis medicamentosa).
Toxicity Common adverse reactions include nervousness, restlessness, and insomnia. Rare adverse reactions include difficult/painful urination, dizziness/lightheadedness, heart palpitations, headache, increased sweating, nausea/vomiting, trembling, troubled breathing, unusual paleness, and weakness.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic.
Absorption Pseudoephedrine is readily and almost completely absorbed from the GI tract and there is no evidence of first-pass metabolism.
Half Life 9-16 hours
Protein Binding Pseudoephedrine does not bind to human plasma proteins over the concentration range of 50 to 2000 ng/mL
External Links
Wikipedia
RxList
Drugs.com

REFERENCES