Leucovorin Calcium

• Catalog No.: S1236
• CAS Number: 6035-45-6
• M. F.: C20H31CaN7O12
• M. W.: 601.57784
• Storage: -20°C

SYNONYMS

• IUPAC name: calcium (2S)-2-[(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioate pentahydrate
• IUPAC Traditional name: calcium(2+) (2S)-2-[(4-{[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioate pentahydrate
• Synonyms: Sodium Folinate; Calcium Folinate

DATABASE IDS

• CAS Number: 6035-45-6

PROPERTIES

• Salt Data: Calcium salt
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Cancer, Metabolic Disease , Endocrinology
Biological Activity:
Human lymphoid cell lines were studied for leucovorin requirements to protect from methotrexate (MTX)-induced growth suppression. Over a 72h continuous exposure leucovorin provided better protection to the cell lines LAZ-007 and RAJI than to the cell lines CCRF-CEM and MOLT-4. [1]Leucovorin is a compound similar to folic acid, which is a necessary vitamin.  It has been around and in use for many decades. Leucovorin is a medication frequently used in combination with the chemotherapy drugs fluoruracil and methotrexate.  Leucovorin is a chemoprotectant, not a chemotherapy drug, however,  it is used in addition to these chemotherapy drugs to enhance anti cancer effects (with fluorouracil) or to help prevent or lessen side effects (with methotrexate). [2]