Evista(Raloxifene Hydrochloride

• Catalog No.: S1227
• CAS Number: 82640-04-8
• M. F.: C28H28ClNO4S
• M. W.: 510.04422
• Storage: -20°C

SYNONYMS

• IUPAC name: 2-(4-hydroxyphenyl)-3-{4-[2-(piperidin-1-yl)ethoxy]benzoyl}-1-benzothiophen-6-ol hydrochloride
• IUPAC Traditional name: 2-(4-hydroxyphenyl)-3-{4-[2-(piperidin-1-yl)ethoxy]benzoyl}-1-benzothiophen-6-ol hydrochloride
• Synonyms: Raloxifene Hydrochloride; keoxifene

DATABASE IDS

• CAS Number: 82640-04-8

PROPERTIES

• Target: estrogen receptor
• Salt Data: Hydrochloride
• Solubility: DMSO
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Cancer
Biological Activity:
Raloxifene has estrogen and tamoxifen-like effects on bone and serum cholesterol levels in ovariectomized rats. At 5 weeks, ovariectomy induced a 9% and 18% decrease in the bone mineral density of the lumbar vertebrae L1-4 and proximal tibiae, respectively. Raloxifene prevented this loss of bone with EC50=0.3 mg/kg/day for both the axial and appendicular skeleton. [1]Raloxifene, which demonstrated an extremely low IC50 value of 2.9 nM for phthalazine oxidase in human liver cytosol. [2]References on Evista(Raloxifene HCl)[] DMD, 2004, 32:89–97

REFERENCES

• Masahiko Sato et al. J Bone Miner Met. 1994