Dacarbazine

• Catalog No.: S1221
• CAS Number: 4342-03-4
• M. F.: C6H10N6O
• M. W.: 182.1832
• Storage: -20°C

SYNONYMS

• IUPAC name: 5-[(1E)-dimethyltriaz-1-en-1-yl]-1H-imidazole-4-carboxamide
• IUPAC Traditional name: dacarbazine
• Synonyms: DTIC; Dtic-Dome

DATABASE IDS

• CAS Number: 4342-03-4

PROPERTIES

• Target: DNA/RNA synthesis
• Salt Data: Free Base
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Cancer
Biological Activity:
Dacarbazine(DTIC-Dome) is an antineoplastic chemotherapy drug used in the treatment of various cancers, among them malignant melanoma, Hodgkin lymphoma, sarcoma, and islet cell carcinoma of the pancreas. [1]Dacarbazine belongs to the family of chemicals known as alkylating agents. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. [2]Dacarbazine is normally administered by injection (a shot) or intravenous infusion (IV) under the immediate supervision of a doctor or nurse. [1]

REFERENCES

• http://www.cancer.gov/drugdictionary/?CdrID=39768