Adrucil(Fluorouracil)

• Catalog No.: S1209
• CAS Number: 51-21-8
• M. F.: C4H3FN2O2
• M. W.: 130.0772232
• Storage: -20°C

SYNONYMS

• IUPAC name: 5-fluoro-1,2,3,4-tetrahydropyrimidine-2,4-dione
• IUPAC Traditional name: fluorouracil
• Synonyms: Fluorouracil; Carac; Efudex; 5-FU; Fluoroplex

DATABASE IDS

• CAS Number: 51-21-8

PROPERTIES

• Target: Antimetabolites
• Salt Data: Free Base
• Solubility: DMSO
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Cancer
Biological Activity:
Fluorouracil (5-FU or f5U) is a chemotherapy drug that is a pyrimidine analog which is used in the treatment of cancer. It works through noncompetitive inhibition of thymidylate synthase. Due to its noncompetitive nature and effects on thymidine synthesis, 5-FU is frequently referred to as the "suicide inactivator". It belongs to the family of drugs called antimetabolites. It is typically administered with leucovorin. [1] Fluorouracil IC50 values were observed across the National Cancer Institute NCI60 panel of human tumor cell lines, which exhibit a mean IC50 of 17.6 μM, with a range of 1–501 μM. [2]

REFERENCES

• http://en.wikipedia.org/wiki/Fluorouracil