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Dutasteride(Avodart)_Molecular_structure_CAS_164656-23-9)
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Dutasteride(Avodart)

Catalog No. S1202 Name Selleck Chemicals
CAS Number 164656-23-9 Website http://www.selleckchem.com
M. F. C27H30F6N2O2 Telephone (877) 796-6397
M. W. 528.5297192 Fax (832) 582-8590
Purity Email sales@selleckchem.com
Storage -20°C Chembase ID: 70499

SYNONYMS

IUPAC name
(1S,2R,7R,10S,11S,14S,15S)-N-[2,5-bis(trifluoromethyl)phenyl]-2,15-dimethyl-5-oxo-6-azatetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-3-ene-14-carboxamide
IUPAC Traditional name
@dutasteride
Synonyms
Avodart

DATABASE IDS

CAS Number 164656-23-9

PROPERTIES

Target 5-alpha-reductase
Salt Data Free Base
Solubility DMSO
Storage Condition -20°C

DETAILS

Description (English)
Research Area: Prostatic intraepithelialn
Biological Activity:
Dutasteride is a 5-alpha-reductase inhibitor that inhibits the conversion of testosterone into dihydrotestosterone (DHT). It is used for the treatment of benign prostatic hyperplasia (BPH) and is prescibed off-label for the treatment of male pattern baldness (MPB). [1]Dutasteride inhibits both isoforms of 5-alpha reductase (5aR1 and 5aR2) to a similar extent (IC50 6nmol/l and 7 nmol/l, respectively), while finasteride only inhibits Type II. [2]Dutasteride competed for binding the LNCaP cell AR with an IC(50) approximately 1.5 µM. [3]References on Dutasteride[] TheProstate, 2004, 58:130^144

REFERENCES

  • http://en.wikipedia.org/wiki/Dutasteride