Dutasteride(Avodart)

• Catalog No.: S1202
• CAS Number: 164656-23-9
• M. F.: C27H30F6N2O2
• M. W.: 528.5297192
• Storage: -20°C

SYNONYMS

• IUPAC name: (1S,2R,7R,10S,11S,14S,15S)-N-[2,5-bis(trifluoromethyl)phenyl]-2,15-dimethyl-5-oxo-6-azatetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-3-ene-14-carboxamide
• IUPAC Traditional name: @dutasteride
• Synonyms: Avodart

DATABASE IDS

• CAS Number: 164656-23-9

PROPERTIES

• Target: 5-alpha-reductase
• Salt Data: Free Base
• Solubility: DMSO
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Prostatic intraepithelialn
Biological Activity:
Dutasteride is a 5-alpha-reductase inhibitor that inhibits the conversion of testosterone into dihydrotestosterone (DHT). It is used for the treatment of benign prostatic hyperplasia (BPH) and is prescibed off-label for the treatment of male pattern baldness (MPB). [1]Dutasteride inhibits both isoforms of 5-alpha reductase (5aR1 and 5aR2) to a similar extent (IC50 6nmol/l and 7 nmol/l, respectively), while finasteride only inhibits Type II. [2]Dutasteride competed for binding the LNCaP cell AR with an IC(50) approximately 1.5 µM. [3]References on Dutasteride[] TheProstate, 2004, 58:130^144

REFERENCES

• http://en.wikipedia.org/wiki/Dutasteride