Finasteride

• Catalog No.: S1197
• CAS Number: 98319-26-7
• M. F.: C23H36N2O2
• M. W.: 372.54414
• Storage: -20°C

SYNONYMS

• IUPAC name: (1S,2R,7R,10S,11S,14S,15S)-N-tert-butyl-2,15-dimethyl-5-oxo-6-azatetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-3-ene-14-carboxamide
• IUPAC Traditional name: finasteride
• Synonyms: Proscar; Propecia

DATABASE IDS

• CAS Number: 98319-26-7

PROPERTIES

• Target: 5α-reductase
• Salt Data: Free Base
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Prostate cancer
Biological Activity:
Finasteride, a synthetic 4-azasteroid antiandrogen compound, is a specific inhibitor of steroid Type II 5α-reductase, an intracellular enzyme that converts the androgen testosterone into 5α-dihydrotestosterone (DHT). [1]Finasteride is used in the treatment of prostate cancer, benign prostatic hyperplasia, and androgenetic alopecia (male pattern baldness). [1]In benign prostatic hyperplasia, finasteride inhibits 5alpha-reductase activity in epithelium for Ki of 10nM, significantly lower than in stroma (Ki = 33nM). [2]References on Finasteride[] J. Steroid Biochem. Molec. Biol., 1998, 67:49-55

REFERENCES

• http://en.wikipedia.org/wiki/Finasteride