Exemestane

• Catalog No.: S1196
• CAS Number: 107868-30-4
• M. F.: C20H24O2
• M. W.: 296.40336
• Storage: -20°C

SYNONYMS

• IUPAC name: (1S,2R,10R,11S,15S)-2,15-dimethyl-8-methylidenetetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,14-dione
• IUPAC Traditional name: exemestane
• Synonyms: Aromasin

DATABASE IDS

• CAS Number: 107868-30-4

PROPERTIES

• Target: aromatase enzyme
• Salt Data: Free Base
• Solubility: DMSO
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Endocrinology
Biological Activity:
Exemestane is an irreversible, oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive breast cancer in postmenopausal women. [1]Its structure was related to the natural substrate androstenedione and it acts as a false substrate for the aromatase enzyme, an effect also known as "suicide inhibition."[1]The estrogen suppression rate for exemestane varies from 85% for estradiol (E2) to 95% for estrone (E1). [1]Exemestane was found to inhibit human placental aromatase with IC50 of 42 nM. [2]References on Exemestane[] Biochimica et Biophysica Acta, 2002, 1587:326– 337

REFERENCES

• http://en.wikipedia.org/wiki/Exemestane