Anastrozole(Arimidex)

• Catalog No.: S1188
• CAS Number: 120511-73-1
• M. F.: C17H19N5
• M. W.: 293.36626
• Storage: -20°C

SYNONYMS

• IUPAC name: 2-[3-(1-cyano-1-methylethyl)-5-(1H-1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile
• IUPAC Traditional name: anastrozole
• Synonyms: AstraZeneca; Arimidex

DATABASE IDS

• CAS Number: 120511-73-1

PROPERTIES

• Target: Aromatase
• Salt Data: Free Base
• Solubility: DMSO
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Endocrinology
Biological Activity:
Anastrozole inhibits the enzyme aromatase, which is responsible for converting androgens to estrogens. Anastrozole binds reversibly to the aromatase enzyme through competitive inhibition.[1] Elevated levels of estrogens may increase the severity of breast cancer, as sex hormones can cause hyperplasia and differentiation at estrogen receptor sites.[1] Anastrozole is used to treat breast cancer after surgery and for metastases in post-menopausal women.[1]

REFERENCES

• http://en.wikipedia.org/wiki/Anastrozole