Ritonavir

• Catalog No.: S1185
• CAS Number: 155213-67-5
• M. F.: C37H48N6O5S2
• M. W.: 720.94422
• Storage: -20°C

SYNONYMS

• IUPAC name: 1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[(2S)-3-methyl-2-{[methyl({[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl})carbamoyl]amino}butanamido]-1,6-diphenylhexan-2-yl]carbamate
• IUPAC Traditional name: ritonavir
• Synonyms: Norvir; Norvir Softgel

DATABASE IDS

• CAS Number: 155213-67-5

PROPERTIES

• Target: HIV protease
• Salt Data: Free Base
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Immunology
Biological Activity:
Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS. It is now rarely used for its own antiviral activity, but remains widely used as a booster of other protease inhibitors. More specifically, ritonavir is used to inhibit a particular liver enzyme that normally metabolizes protease inhibitors, cytochrome P450-3A4 (CYP3A4). The drug’s molecular structure inhibits CYP3A4, so a low dose can be used to enhance other protease inhibitors. This discovery has drastically reduced the adverse effects and improved the efficacy of PI’s and HAART. [1]

REFERENCES

• http://en.wikipedia.org/wiki/Ritonavir