ABT-888

• Catalog No.: S1004
• CAS Number: 912444-00-9
• M. F.: C13H16N4O
• M. W.: 244.29234
• Storage: -20°C

SYNONYMS

• IUPAC name: 2-[(2R)-2-methylpyrrolidin-2-yl]-1H-1,3-benzodiazole-4-carboxamide
• IUPAC Traditional name: 2-[(2R)-2-methylpyrrolidin-2-yl]-1H-1,3-benzodiazole-4-carboxamide
• Synonyms: Veliparib

DATABASE IDS

• CAS Number: 912444-00-9

PROPERTIES

• Target: PARP
• Salt Data: Free Base
• Solubility: DMSO
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area

• Description: Cancer

Protocol

• Protocol: Kinase Assay ^[1]
• In vitro PARP assays: PARP assays are conducted in a buffer containing 50 mM Tris (pH 8.0), 1 mM DTT, 1.5 μM [^3H]NAD^+ (1.6 μCi/mmol), 200 nM biotinylated histone H1, 200 nM slDNA, and 1 nM PARP-1 or 4 nM PARP-2 enzyme. Reactions are terminated with 1.5 mM benzamide, transferred to streptavidin Flash plates, and counted using a TopCount microplate scintillation counter.
• Protocol: Animal Study ^[1]
• Animal Models: NCI-H460, H460, B16F10 and 9L xenografts in C57BL/6 mice
• Formulation: Formulated in solution containing 0.9% NaCl adjusted to pH 4.0
• Doses: ~25 mg/kg
• Administration: Orally administered

References

• References: [1] Donawho CK, et al, Clin Cancer Res, 2007, 13 (9), 2728-2737.
• References: [2] Penning TD, et al, J Med Chem, 2009, 52(2), 514-523.
• References: [3] Albert JM, et al, Clin Cancer Res, 2007, 13(10), 3033-3042.
• References: [4] Kinders RJ, et al, Clin Cancer Res, 2008, 14(21), 6877-6885.
• References: [5] Kinders RJ, et al, Clin Cancer Res, 2008, 14(21), 6877-6885.
• References: [6] Horton TM, et al. 2007 ASCO Annual Meeting, Abstract 9528.
• References: [7] Liu X, et al. Mol Cancer Res, 2009, 7(10), 1686-1692.
• References: [8] Palma JP, et al. Clin Cancer Res, 2009, 15(23), 7277-7290.
• References: [9] Horton TM, et al. ASCO Annual Meeting, 2007, Abs 9528.
• References: [10] Clark CC, et al. Mol Cancer Ther, 2012 Jul 9.

REFERENCES

• Kinders RJ, et al, Clin Cancer Res, 2008, 14(21), 6877-6885.
• Clark CC, et al. Mol Cancer Ther, 2012 Jul 9.
• Donawho CK, et al, Clin Cancer Res, 2007, 13 (9), 2728-2737.
• Penning TD, et al, J Med Chem, 2009, 52(2), 514-523.
• Albert JM, et al, Clin Cancer Res, 2007, 13(10), 3033-3042.
• Kinders RJ, et al, Clin Cancer Res, 2008, 14(21), 6877-6885.
• Horton TM, et al. 2007 ASCO Annual Meeting, Abstract 9528.
• Liu X, et al. Mol Cancer Res, 2009, 7(10), 1686-1692.
• Palma JP, et al. Clin Cancer Res, 2009, 15(23), 7277-7290.
• Horton TM, et al. ASCO Annual Meeting, 2007, Abs 9528.