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Cysteamine

Catalog No. DB00847 Name DrugBank
CAS Number 60-23-1 Website http://www.ualberta.ca/
M. F. C2H7NS Telephone (780) 492-3111
M. W. 77.14868 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 725

SYNONYMS

IUPAC name
2-aminoethane-1-thiol
IUPAC Traditional name
cysteamine
Brand Name
Lambraten
Mecramine
Mercamin
Merkamin
Becaptan
Lambratene
Riacon
Cystavision
Synonyms
beta-MEA
MEA
Mercamine
2-Aminoethyl mercaptan
Cysteinamine
2-Amino-1-ethanethiol
2-Aminoethanethiol
beta-Aminoethanethiol
beta-Mercaptoethylamine
Cysteamin
Ethanethiolamine
Cysteamine hydrochloride
(2-Mercaptoethyl)amine
2-Mercaptoethanamine
Aminoethyl mercaptan
Cisteamina
Cysteamide
Cysteamine bitartrate
Decarboxycysteine
Mercaptamin
Thioethanolamine

DATABASE IDS

PubChem SID 46507730
CAS Number 60-23-1
PubChem CID 6058

PROPERTIES

Hydrophobicity(logP) 0.1

DETAILS

Description (English)
Item Information
Drug Groups approved; investigational
Description A radiation-protective agent that oxidizes in air to form cystamine. It can be given intravenously or orally to treat radiation sickness. The bitartrate has been used for the oral treatment of nephropathic cystinosis. [PubChem]
Indication Given intravenously or orally to treat radiation sickness. The bitartrate has been used for the oral treatment of nephropathic cystinosis and cystinurea.
Pharmacology People born without the ability to metabolize the amino acid cystine suffer from cystinosis, a rare inherited disorder characterized by the deposition and accumulation of cystine crystals throughout the body. These crystals cause considerable damage, particularly in the kidney. Kidney failure can occur by the age of 10 in untreated patients. Cysteamine prevents the accumulation of cystine crystals and is prescribed to prevent further kidney damage. Cysteamine helps to convert cystine into less harmful chemical forms that can be removed from cells.
Toxicity Symptoms of overdose may include convulsions (seizures), increased thirst and unusual tiredness or weakness.
Affected Organisms
Humans and other mammals
Distribution * 156 L
Clearance * apparent plasma cl=1.2 L/min
References
Lukashin BP, Grebeniuk AN: [Comparative study of the radiation-protective effectiveness of low doses of cysteamine, heparin, and naphtizine in experiments on mice] Radiats Biol Radioecol. 2001 May-Jun;41(3):310-2. [Pubmed]
External Links
Wikipedia
Drugs.com

REFERENCES

  • Lukashin BP, Grebeniuk AN: [Comparative study of the radiation-protective effectiveness of low doses of cysteamine, heparin, and naphtizine in experiments on mice] Radiats Biol Radioecol. 2001 May-Jun;41(3):310-2. Pubmed