3-Chloro-3-methyl-1-butyne

• Catalog No.: B25252
• CAS Number: 1111-97-3
• M. F.: C5H7Cl
• M. W.: 102.56208
• Purity: 95%

SYNONYMS

• Title: 3-氯-3-甲基-1-丁炔
• IUPAC name: 3-chloro-3-methylbut-1-yne
• IUPAC Traditional name: 1-butyne, 3-chloro-3-methyl-
• Synonyms: 1,1-Dimethylpropargyl chloride

DATABASE IDS

• MDL Number: MFCD00190221
• CAS Number: 1111-97-3
• EC Number: 214-188-9

PROPERTIES

• Purity: 95%
• Boiling Point: 73-75°C
• Density: 0.913
• Flash Point: 4°C(40°F)
• Melting Point: -61°C
• Refractive Index: 1.4178
• GHS Hazard statements: H225-H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• European Hazard Symbols: Flammable (F)
• GHS Precautionary statements: P210-P241-P303+P361+P353-P305+P351+P338-P405-P501A
• Risk Statements: 11-36/37/38
• Safety Statements: 16-26-29-33-37
• TSCA Listed: 是
• Hazard Class: 3
• UN Number: UN1993
• Packing Group: II

REFERENCES

• Reagent for an improved 2-step introduction of the 1,1-dimethylallyl (DMA) ester protecting group for carboxylic acids. Reaction with the acid in the presence of copper(I) iodide and cesium carbonate in DMF affords the 1,1-dimethylpropargyl ester. Hydrogenation with Pd/barium sulfate/quinoline affords the 1,1-dimethylallyl ester. The DMA group is resistant to nucleophilic attack, but readily cleaved under non-acidic conditions with Pd(0), which is an advantage compared with the tert-butyl ester in solid-phase peptide synthesis: Org. Lett., 7, 1473 (2005).