1H-Benzotriazol-1-yloxytri(1-pyrrolidinyl)phosphonium hexafluorophosphate

• Catalog No.: B25251
• CAS Number: 128625-52-5
• M. F.: C18H28F6N6OP2
• M. W.: 520.3924612
• Purity: 98%

SYNONYMS

• Title: 1H-苯并三唑-1-氧基三(1-吡咯烷基)膦六氟磷酸盐
• IUPAC name: (1H-1,2,3-benzotriazol-1-yloxy)tris(pyrrolidin-1-yl)phosphanium; hexafluoro-λ^5-phosphanuide
• IUPAC Traditional name: PyBOP hexafluorophosphate
• Synonyms: PyBOP

DATABASE IDS

• Beilstein Number: 3584612
• CAS Number: 128625-52-5
• EC Number: 000-000-0
• MDL Number: MFCD00077411

PROPERTIES

• Safety Statements: 26-37
• Storage Warning: Moisture Sensitive
• TSCA Listed: 否
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P261-P305+P351+P338-P302+P352-P321-P405-P501A
• Risk Statements: 36/37/38
• Purity: 98%
• Melting Point: ca 155°C dec.

REFERENCES

• Low racemization peptide coupling reagent (see Appendix 6), introduced by Castro, analogous to BOP Reagent (1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate, A16140) but avoiding the formation of the carcinogenic HMPA as a by-product: Tetrahedron Lett., 31, 205 (1990). For use in formation of mixed phosphonate diesters, see: J. Org. Chem., 60, 5214 (1995).