2-Chloro-4,6-dimethoxy-1,3,5-triazine

• Catalog No.: B24474
• CAS Number: 3140-73-6
• M. F.: C5H6ClN3O2
• M. W.: 175.57304
• Purity: 98%

SYNONYMS

• Title: 2-氯-4,6-二甲氧基-1,3,5-三嗪
• IUPAC name: 2-chloro-4,6-dimethoxy-1,3,5-triazine
• IUPAC Traditional name: 2-chloro-4,6-dimethoxy-1,3,5-triazine

DATABASE IDS

• MDL Number: MFCD00075607
• EC Number: 221-541-0
• CAS Number: 3140-73-6
• Beilstein Number: 148988

PROPERTIES

• Purity: 98%
• Boiling Point: 99-100°C/1mm
• Melting Point: 75-79°C
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P261-P305+P351+P338-P302+P352-P321-P405-P501A
• Risk Statements: 36/37/38
• Safety Statements: 26-37-60
• TSCA Listed: 否

REFERENCES

• Similarly, carboxylic acids are converted to Weinreb amides by reaction with N,O-dialkyl hydroxylamines: J. Org. Chem., 66, 2534 (2001).
• Reagent for activation of carboxylic acids to nucleophiles: J. Org. Chem., 63, 4248 (1998). Peptide coupling reagent: Synthesis, 917 (1987). With N-methylmorpholine forms the quaternary chloride (DMTMM) which is a valuable low-cost coupling agent in solid-phase peptide synthesis: Synlett, 275 (2000). For a reexamination of the use of the reagent in peptide coupling, see: Tetrahedron Lett., 42, 4161 (2002); see also Appendix 6.
• Can also be used for the esterification of carboxylic acids: Synthesis, 593 (1999). The intermediate active esters can be hydrogenolyzed, providing a simple method for reduction of acids to aldehydes; at higher pressures, further reduction to the alcohol can be effected: J. Org. Chem., 64, 8962 (1999).