Polyethylene glycol 400

• Catalog No.: B21992
• CAS Number: 25322-68-3
• M. F.: C2H6O2
• M. W.: 62.06784

SYNONYMS

• Title: 聚乙二醇 400
• IUPAC name: ethane-1,2-diol
• IUPAC Traditional name: ethylene glycol
• Synonyms: PEG 400

DATABASE IDS

• Merck Index: 147568
• MDL Number: MFCD01779601
• CAS Number: 25322-68-3

PROPERTIES

• Melting Point: 4-8°C
• Refractive Index: 1.4660
• TSCA Listed: 是

REFERENCES

• Polyethylene glycols can act as effective solvents and low-cost phase-transfer catalysts by complexing with cations (see Appendix 2). Examples of reactions promoted by these species:
• Nucleophilic displacements of benzyl halides: Synthesis, 184 (1977). Permanganate oxidations: J. Org. Chem., 43, 1532 (1978); Tetrahedron Lett., 3543 (1979). Dichromate oxidations; similar results to carcinogenic HMPA, and to crown ethers.
• Good solvent for borohydride reductions: Tetrahedron Lett., 4581 (1979). Stereoselective reduction of alkynes to cis-alkenes using NaBH₄ and a catalytic amount of PdCl₂ in dichloromethane-PEG: J. Chem. Soc., Chem. Commun., 515 (1982).
• Wacker oxidation of olefins to methyl ketones: Tetrahedron Lett., 26, 2263 (1985). Conversion of acids to peracids; see Potassium peroxydisulfate, A15310. Recyclable medium for rapid Baylis-Hillman reactions (see Ammonium bismuth citrate, A17003): Tetrahedron Lett., 45, 5865 (2004).