3-Quinuclidinol

• Catalog No.: B21503
• CAS Number: 1619-34-7
• M. F.: C7H13NO
• M. W.: 127.18422
• Purity: 98+%

SYNONYMS

• Title: 3-喹核醇
• IUPAC name: 1-azabicyclo[2.2.2]octan-3-ol
• IUPAC Traditional name: 1-azabicyclo 2.2.2 octan-3-ol
• Synonyms: 1-Azabicyclo[2.2.2]octan-3-ol; 3-Hydroxyquinuclidine

DATABASE IDS

• EC Number: 216-578-4
• CAS Number: 1619-34-7
• Beilstein Number: 104327
• Merck Index: 148082
• MDL Number: MFCD00151326

PROPERTIES

• Purity: 98+%
• Melting Point: 217-224°C
• GHS Hazard statements: H314-H318
• European Hazard Symbols: Corrosive (C)
• GHS Precautionary statements: P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501A
• Risk Statements: 34
• RTECS: VD6191700
• Safety Statements: 26-36/37/39-45
• Storage Warning: Air Sensitive
• TSCA Listed: 是
• Hazard Class: 8
• UN Number: UN3263
• Packing Group: III

REFERENCES

• Reagent for selective cleavage of ?-keto esters to ketones in high yield: Synth. Commun., 5, 341 (1975). Geminal diesters are converted to monoesters in high yield under similar conditions: J. Org. Chem., 41, 208 (1976).
• Superior catalyst for the Baylis-Hillman reaction: the addition of acrylic esters to aldehydes, often very slow (4-7 days) with the usual catalyst 1,4-Diazabicyclo[2.2.2]octane, A14003, is much faster (<1 day) in the presence of quinuclidinol: Synth. Commun., 18, 495 (1988); Tetrahedron Lett., 32, 5611 (1991). For more recent discussion and methodology, see: J. Org. Chem., 67, 510 (2002); 68, 692 (2003). For reviews of the Baylis-Hillman reaction, see: Tetrahedron, 44, 4653 (1988); 52, 8001 (1996). The rate of addition of enones to aldehydes is similarly enhanced: Synth. Commun., 18, 495 (1988); 19, 959 (1989).