2-(Trimethylsilyl)ethanol

• Catalog No.: B20970
• CAS Number: 2916-68-9
• M. F.: C5H14OSi
• M. W.: 118.24956
• Purity: 98+%

SYNONYMS

• Title: 2-(三甲基硅基)乙醇
• IUPAC name: 2-(trimethylsilyl)ethan-1-ol
• IUPAC Traditional name: 2-(trimethylsilyl)ethanol
• Synonyms: 2-Hydroxyethyltrimethylsilane

DATABASE IDS

• MDL Number: MFCD00002825
• CAS Number: 2916-68-9
• Beilstein Number: 1732034
• EC Number: 220-844-5

PROPERTIES

• Purity: 98+%
• Boiling Point: 71-72°C/10mm
• Density: 0.825
• Flash Point: 50°C(122°F)
• Refractive Index: 1.4250
• GHS Hazard statements: H226-H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P210-P241-P303+P361+P353-P305+P351+P338-P405-P501A
• Risk Statements: 10-36/37/38
• RTECS: KM5480000
• Safety Statements: 26-37
• TSCA Listed: 否
• Hazard Class: 3
• UN Number: UN1987
• Packing Group: III

REFERENCES

• Carboxyl groups can be protected as 2-(trimethylsilyl)ethyl (TMSE) esters by carbodiimide coupling: Helv. Chim. Acta, 60, 2711 (1977); J. Org. Chem., 62, 93 (1997), from the acid chloride in pyridine: Helv. Chim. Acta, 60, 3039 (1977), or refluxing the acid in THF in the presence of TMS chloride: J. Am. Chem. Soc., 106, 3030 (1984). The TMSE protecting group is useful in peptide synthesis. Cleavage is readily effected with TBAF in DMF or DMSO: Helv. Chim. Acta, 60, 2711 (1977); Bioorg. Med. Chem. Lett., 3, 437 (1993).