2,3-Dihydrofuran

• Catalog No.: B20575
• CAS Number: 1191-99-7
• M. F.: C4H6O
• M. W.: 70.08984
• Purity: 98+%

SYNONYMS

• Title: 2,3-二氢呋喃
• IUPAC name: 2,3-dihydrofuran
• IUPAC Traditional name: 2,3-dihydrofuran

DATABASE IDS

• CAS Number: 1191-99-7
• Beilstein Number: 103168
• MDL Number: MFCD00003205
• EC Number: 214-747-7

PROPERTIES

• Purity: 98+%
• Boiling Point: 54-55°C
• Density: 0.927
• Flash Point: -24°C(-11°F)
• Refractive Index: 1.4245
• GHS Hazard statements: H225-H301-H319
• European Hazard Symbols: X
• European Hazard Symbols: Flammable (F)
• GHS Precautionary statements: P210-P301+P310-P303+P361+P353-P305+P351+P338-P405-P501A
• Risk Statements: 11-19-22-36
• Safety Statements: 9-16-26-33-36
• TSCA Listed: 是
• Hazard Class: 3
• UN Number: UN3271
• Packing Group: II

REFERENCES

• For lithiation at the 5-position, see: Tetrahedron Lett., 4187 (1977); Org. Synth. Coll., 9, 530 (1998). For alkylation by active methylene compounds, catalyzed by trans-Dichlorobis(triphenylphosphine)palladium(II), 10491, see: J. Org. Chem., 47, 2812 (1982). For catalytic asymmetric arylation, see: J. Am. Chem. Soc., 113, 1417 (1991); Pure Appl. Chem., 64, 421 (1992).
• Forms tetrahydrofuranyl esters (acyl hemiacetals) with carboxylic acids. These react with Grignard reagents to give good yields of ketones with minimal enolization or double addition (tertiary alcohol formation). The utility of other acyl hemiacetals as ketone precursors has also been studied: J. Org. Chem., 61, 6071 (1996):