Acetonitrile

• Catalog No.: A19862
• CAS Number: 75-05-8
• M. F.: C2H3N
• M. W.: 41.05192
• Purity: 99%

SYNONYMS

• Title: 乙腈
• IUPAC name: acetonitrile
• IUPAC Traditional name: acetonitrile
• Synonyms: Cyanomethane; Methyl cyanide

DATABASE IDS

• CAS Number: 75-05-8
• Merck Index: 1470
• MDL Number: MFCD00001878
• EC Number: 200-835-2
• Beilstein Number: 741857

PROPERTIES

• Purity: 99%
• Boiling Point: 80-82°C
• Density: 0.786
• Flash Point: 5°C(41°F)
• Melting Point: -48°C
• Refractive Index: 1.3440
• GHS Hazard statements: H225-H302-H312-H332-H319
• European Hazard Symbols: X
• European Hazard Symbols: Flammable (F)
• GHS Precautionary statements: P210-P241-P303+P361+P353-P305+P351+P338-P403+P235-P501A
• Risk Statements: 11-20/21/22-36
• RTECS: AL7700000
• Safety Statements: 16-36/37
• TSCA Listed: 是
• Hazard Class: 3
• UN Number: UN1648
• Packing Group: II

REFERENCES

• For use in the mild conversion of amides to nitriles, see Benzamide, A10501.
• Polar aprotic solvent for a wide variety of reactions, including nucleophilic substitutions, oxidations, reductions and organometallic reactions. Widely used with crown ethers for the generation of 'naked' anions from their salts; see, e.g. 18-Crown-6, A11249. Preferred solvent for RuO₄ oxidations, due to its coordinating ability; see Ruthenium(III) chloride hydrate, 11043.
• Undergoes the Ritter reaction with alcohols or olefins in the presence of acid to give N-substituted acetamides. For benzylic alcohols, modified conditions employing boron trifluoride etherate give high yields: Synth. Commun., 24, 601 (1994). For an example, see 4-Methylbenzyl alcohol, A15315.